The episode begins with Gumball, Darwin and Anais have a pillow fight. Nicole then comes in their room and tells the boys to hurry up or they'll miss the bus to school. However, once in the school, Darwin starts sneezing and can't stop. As the sneezes grow more powerful Gumball and Darwin consult the school nurse, who confirms that the problem is a simple allergy that can be ignored. However, the sneezes continue to escalate and become more and more destructive. Mr. Small tries to help Darwin using highly questionable "alternative medicine", but to no avail.

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